specific noo noo's causing you problems? let's check it out!

Let’s look at the specific gut microbes that are linked to Hashimoto’s, Rheumatoid Arthritis (RA), Lupus (SLE), and Psoriasis — both harmful strains that worsen these conditions, and beneficial strains that can help reduce symptoms.

🧫 GUT MICROBIOME & AUTOIMMUNE DISEASE LINKS

1. Hashimoto’s Thyroiditis

🚨 Harmful gut microbes (increased in Hashimoto’s):

• Prevotella spp. – Promotes Th17 inflammation and disrupts mucosal tolerance

• Klebsiella pneumoniae – Linked to cross-reactivity with thyroid tissue

• Yersinia enterocolitica – Molecular mimicry potential (triggers thyroid antibodies)

• Proteobacteria overgrowth – Linked with leaky gut and systemic inflammation

✅ Helpful microbes (often decreased):

• Lactobacillus reuteri – Regulates thyroid axis and inflammation

• Bifidobacterium longum – Supports mucosal immunity and Treg cells

• Akkermansia muciniphila – Improves gut barrier and insulin sensitivity

• Faecalibacterium prausnitzii – Produces butyrate; anti-inflammatory

2. Rheumatoid Arthritis (RA)

🚨 Harmful microbes (increased in RA):

• Prevotella copri – Strongly linked to early RA onset; promotes immune dysregulation

• Collinsella aerofaciens – Alters gut permeability and promotes IL-17

• Eggerthella lenta – Increases inflammation and disease severity

• Actinobacteria imbalance – Associated with pro-inflammatory T-cell activity

✅ Helpful microbes (often reduced):

• Lactobacillus casei – Reduces joint inflammation

• Bacteroides fragilis (non-toxigenic) – Promotes Treg development

• Faecalibacterium prausnitzii – Suppresses TNF-α and IL-6

• Roseburia spp. – Butyrate producer, supports gut lining

3. Lupus (Systemic Lupus Erythematosus – SLE)

🚨 Harmful microbes (increased in lupus):

• Ruminococcus gnavus – Major lupus trigger; activates TLRs and flares

• Lachnospiraceae imbalance – Increases intestinal permeability

• Clostridium spp. (pathogenic types) – Disrupts immune signaling

• Bacteroides dorei – Associated with autoantibody production

✅ Helpful microbes (often reduced):

• Bifidobacterium bifidum – Modulates immune activity

• Lactobacillus fermentum & plantarum – Supports Treg cells and gut barrier

• Akkermansia muciniphila – Helps prevent flares by regulating mucus lining

• Bacteroides vulgatus (at proper levels) – May balance gut immunity

4. Psoriasis (and Psoriatic Arthritis)

🚨 Harmful microbes (overgrown in psoriasis):

• Escherichia coli (pathogenic strains) – Promotes gut-skin axis inflammation

• Streptococcus spp. – Can trigger molecular mimicry (especially with guttate psoriasis)

• Candida albicans (yeast) – Often overgrown; linked to flare severity

• Firmicutes/Bacteroidetes imbalance – Common in gut dysbiosis of psoriasis patients

✅ Helpful microbes (deficient in psoriasis):

• Lactobacillus salivarius – Helps reduce skin lesions

• Bifidobacterium breve – Improves skin barrier and inflammation

• Faecalibacterium prausnitzii – Major anti-inflammatory action via butyrate

• Butyricicoccus pullicaecorum – Supports gut barrier and skin health

🧠 Summary Table

Autoimmune Condition	Harmful Microbes	Beneficial Microbes
Hashimoto’s	Prevotella, Yersinia, Klebsiella	L. reuteri, B. longum, A. muciniphila
RA	P. copri, Collinsella, Eggerthella	L. casei, F. prausnitzii, Roseburia
Lupus	R. gnavus, Clostridia, B. dorei	B. bifidum, L. fermentum, Akkermansia
Psoriasis	Candida, E. coli, Streptococcus	L. salivarius, B. breve, F. prausnitzii

Crazy right!!!!! These guys need to go.

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