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The Impact of Chronic Medications on Methylation


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Did you know that these common medications reduce Methylation?

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Common medications may be reducing your ability to methylate by lowering vitamin B12 and your overall folate (vitamin B9) levels. If less vitamin B12 and/or folate is available to use in your body, symptoms may become worse.

Medications that could be interfering with your B12 and folate
levels include:

  • Antacids (medications used to treat heartburn, indigestion and reflux)

  • Cholestyramine (medication for high cholesterol)

  • Nitrous oxide – (your dentist will often use this. It’s known as laughing gas)

  • Methotrexate- (this may be used in cancer or autoimmune disease)

  • Niacin (at high doses) – because Niacin uses methyl groups in its metabolism

  • Theophylline – (a medication used to treat asthma and chronic obstructive pulmonary disease - COPD)

  • Cyclosporin – (used as an immunosuppressant, commonly used with people who have auto immunities and inflammatory conditions)

  • Metformin – (used to treat high blood sugar levels)

  • Phenytoin – (is an anti-epileptic drug, also called an anticonvulsant)

  • Bactrim – (an antibiotic)

  • Sulfasalazine – (is used to treat ulcerative colitis and Crohns disease, and other types of inflammatory bowel disease. It can also be used to treat rheumatoid arthritis)

  • Triamterene – (a type of diuretic (water pill) that helps prevent your body from losing too much potassium)

  • Trimethoprim - (it is an antibiotic used to treat and prevent urinary tract infections (UTIs), such as cystitis)

  • Oral contraceptive pill

  • Anti-malarials


Symptoms of low vitamin B12 and low Folate (Vitamin B9) are the following:


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Should you wish to find out if your meds are creating a deficiency in these most important vitamins book an appointment on 083 654 9943 or bookingsatessentialhealth@gmail.com




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