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The Impact of Chronic Medications on Methylation



Did you know that these common medications reduce Methylation?




Common medications may be reducing your ability to methylate by lowering vitamin B12 and your overall folate (vitamin B9) levels. If less vitamin B12 and/or folate is available to use in your body, symptoms may become worse.

Medications that could be interfering with your B12 and folate
levels include:

  • Antacids (medications used to treat heartburn, indigestion and reflux)

  • Cholestyramine (medication for high cholesterol)

  • Nitrous oxide – (your dentist will often use this. It’s known as laughing gas)

  • Methotrexate- (this may be used in cancer or autoimmune disease)

  • Niacin (at high doses) – because Niacin uses methyl groups in its metabolism

  • Theophylline – (a medication used to treat asthma and chronic obstructive pulmonary disease - COPD)

  • Cyclosporin – (used as an immunosuppressant, commonly used with people who have auto immunities and inflammatory conditions)

  • Metformin – (used to treat high blood sugar levels)

  • Phenytoin – (is an anti-epileptic drug, also called an anticonvulsant)

  • Bactrim – (an antibiotic)

  • Sulfasalazine – (is used to treat ulcerative colitis and Crohns disease, and other types of inflammatory bowel disease. It can also be used to treat rheumatoid arthritis)

  • Triamterene – (a type of diuretic (water pill) that helps prevent your body from losing too much potassium)

  • Trimethoprim - (it is an antibiotic used to treat and prevent urinary tract infections (UTIs), such as cystitis)

  • Oral contraceptive pill

  • Anti-malarials


Symptoms of low vitamin B12 and low Folate (Vitamin B9) are the following:





Should you wish to find out if your meds are creating a deficiency in these most important vitamins book an appointment on 083 654 9943 or bookingsatessentialhealth@gmail.com




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